Prof. Peng Zhan
Research areas
Pharmacology & Pharmacy, Biochemistry & Molecular Biology, Chemistry, Virology, Science & Technology
Research activities
Recent Publications/Highlighted Publications
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Discovery of a Novel Thienopyrimidine Derivative as a Potent Dual URAT1/GLUT9 Inhibitor with Enhanced Urate-Lowering Efficacy, Superior Pharmacokinetics, and Favorable Safety Profile for Gout and Hyperuricemia |
Journal of Medicinal Chemistry (2026) |
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Antiviral drug discovery and development: challenges and future directions |
Signal Transduction and Targeted Therapy (2026) |
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Breakthrough progress in the structural determination of the monkeypox virus I7L protease and the design of targeted inhibitors |
Chinese Chemical Letters (2026) |
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Structural biology of HIV-1 reverse transcriptase allosteric inhibitors for drug design |
ACTA Pharmaceutica Sinica B (2026) |
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Clinical insight-driven novel drug development: Multidisciplinary integration and transformative opportunities |
ACTA Pharmaceutica Sinica B (2026) |
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Discovery of novel diarylpyrimidine derivatives as HIV-1 non-nucleoside reverse transcriptase inhibitors: Design, synthesis and biological activity evaluation |
Bioorganic Chemistry (2026) |
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First-in-Class Quinoline-Dione-Derived PROTACs: Potent Degraders of Cdc25 Phosphatases for Antitumor Therapy |
Journal of Medicinal Chemistry (2026) |
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Design, Synthesis, and Biological Evaluation of Highly Potent Boronic Acid (Boronate Ester)-Bearing Heteroaryldihydropyrimidine Derivatives as HBV Capsid Assembly Modulators |
Journal of Medicinal Chemistry (2025) |
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Phenotypic Screening: A Cornerstone Engine for Discovering Original Anti-Infective Drugs |
Journal of Medicinal Chemistry (2025) |
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Recent Advances in Long-Acting Antiviral Agents: Innovations in Design and Strategies for Extended Duration |
Journal of Medicinal Chemistry (2026) |
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Decoding helical dynamics in viral replication: Cryo-EM unveils conserved assembly mechanisms and broad-spectrum antiviral targets |
ACTA Pharmaceutica Sinica B (2025) |
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Stories behind drug discovery: Key figures, cutting-edge technologies, and blockbuster drugs |
Innovation (2025) |
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Novel oxadiazole analogs as anticancer agents: Design, synthesis, in vitro and in vivo biological evaluation, and computer studies of sphingosine kinase inhibitors |
Bioorganic & Medicinal Chemistry (2026) |
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Strategies for developing anti-CHIKV drugs |
Science China-Chemistry (2026) |
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Protein degradation-based anti-infective drug research |
ACTA Pharmaceutica Sinica B (2025) |
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Therapeutic approaches to addressing drug resistance by targeting membranes and associated structures |
Drug Discovery Today (2025) |
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Multisite Occupancy and Multidimensional Optimization: Design and Evaluation of Piperazine-Thioureidobenzamide Derivatives as Potent HBV Capsid Assembly Modulators |
Journal of Medicinal Chemistry (2025) |
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Structure- and Privileged Fragment-Based Iterative Optimization: Discovery of 2,4-Disubstituted-6-aminopyrimidines as Novel HIV-1 NNRTIs with Potent Activity against Drug-Resistant Strains and Favorable Safety Profiles |
Journal of Medicinal Chemistry (2025) |
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Antiviral strategies based on targeted protein degradation: An overview of the literature and future outlook |
European Journal of Medicinal Chemistry (2026) |
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Exploring the HIV-1 Reverse Transcriptase p51/p66 Interface: Structure-Based Design and Optimization of Novel 2,4,6-Trisubstituted Pyrimidines as Potent NNRTIs with Improved Resistance Profiles |
Journal of Medicinal Chemistry (2025) |
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Discovery of a Baloxavir-Inspired Endonuclease Inhibitor That Prevents Herpes Simplex Virus 1 Replication in Cell Culture and In Vivo |
Advanced Science (2025) |
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Anti-infective Drug Discovery: Harnessing Multimechanistic Molecules and Emergent Properties to Defeat Pathogenic Complexity |
Journal of Medicinal Chemistry (2025) |
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Advances in click chemistry for drug discovery and development |
Expert Opinion On Drug Discovery (2025) |
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Design, synthesis, and biological evaluation of dual-site HIV-1 inhibitors simultaneously targeting the NNRTI binding pocket and an adjacent site with favorable resistance profiles |
Bioorganic Chemistry (2025) |
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ROS-induced allosteric regulation of NikR coordinates HP0910-mediated OMP2 methylation to modulate H. pylori biofilm dynamics and therapeutic targeting |
Microbiological Research (2025) |
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Targeting the coronavirus membrane protein: A promising novel therapeutic strategy |
ACTA Pharmaceutica Sinica B (2025) |
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Structural Analysis of HIV-1 RNase H Bound to a Galloyl Active Site Inhibitor and Computational Compound Modification |
Biochemistry (2025) |
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Discovery of multi-target anti-gout agents from Eurycoma longifolia Jack through phenotypic screening and structural optimization |
Nature Communications (2025) |
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Structure-Based Drug Design Yields Diarylpyrimidine Derivatives as Potent HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors |
ACS Infectious Diseases (2025) |
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Further exploring the tolerant region II: Identification of 2,4,5-trisubsti-tuted pyrimidines as HIV-1 reverse transcriptase allosteric inhibitors with desirable antiviral activities and reduced cytotoxicity |
European Journal of Medicinal Chemistry (2025) |
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Research projects |
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National Natural Science Foundation of China (NSFC), Contract grant numbers: 81573347 |
2016.01-2019.12 |
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National Natural Science Foundation of China (NSFC), Contract grant numbers: 81102320 |
2012.01-2014.12 |
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Research Fund for the Doctoral Program of Higher Education of China, Contract grant number: 20110131120037 |
2012.01-2015.12 |
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The Science and Technology Development Project of Shandong Province, Contract grant number: 2014GSF118012 |
2015.01-2017.12 |
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The Special Program of the Postdoctoral Science Foundation of China, Contract grant number: 2012T50584 |
2012.10-2013.10 |
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The General Program of the Postdoctoral Science Foundation of China, Contract grant number: 20100481282 |
2011.01-2012.12 |
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Research Project funded by JSPS (Japan Society for the Promotion of Science), Contract grant number: 12F02418 |
2012-2013 |
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Shangdong Postdoctoral Innovation Science Research Special Program, Contract grant number: 201002023 |
2011.1-2013.06 |
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Independent Innovation Foundation of Shandong University (IIFSDU), Contract grant number: 2010GN044 |
2010.10-2012.12 |
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Patents |
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Preparation of imidazole derivatives as antitumor drugs. Faming Zhuanli Shenqing |
2014 |
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Preparation of heterocyclic compounds as anti-HIV agents. Faming Zhuanli Shenqing |
2011 |
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Preparation of heterocycles useful for preventing and treating HIV and influenza virus infection |
2010 |
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Method for preparation of 2-(2-substituted aryl-2H-1,2,4-triazole-3-mercapto)acetamide derivatives, and the preparation and medical application as anti-AIDS agent |
2010 |
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A process for preparing 2-(1,2,3-thiadiazol-5-ylthio)-acetamide derivatives |
2009 |
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Preparation of 1,2,3-selenadiazole derivatives as HIV inhibitors |
2009 |
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Preparation of 1-aryl-2-mercaptoimidazole derivatives as HIV-1 inhibitors |
2009 |
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Preparation of 2-[(4-phenyl-1,2,3-thiadiazol-5-yl)thio]-N-phenyl- acetamide derivatives as anti-HIV agents |
2009 |
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Imidazopyrazine derivatives as antiviral agents and their preparation, pharmaceutical compositions and use in the treatment of HIV infection |
2014 |
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2H-1,2,6-Thiadiazin-3(6H)-one-1,1-dioxide derivatives as antiviral agents and their preparation, pharmaceutical compositions and use in the treatment of HIV-1 infection |
2014 |
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Preparation of pyrimidine mercapto-acetamides derivatives. Faming Zhuanli Shenqing |
2014 |
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Substituted pyrazolo[1,5-a]pyrimidine derivative, its preparation method and application in preparation of drug for treatment and prevention of human immunodeficiency virus (HIV) infection |
2014 |
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m-Diarene-pyrimidine derivatives as HIV-1 reverse transcriptase inhibitors and their preparation, pharmaceutical compositions and use in the treatment of HIV infection |
2014 |
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Preparation of substituted thiadiazine triketone derivatives for preventing and treating AIDS |
2013 |
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Triazolopyrimidines as HIV-1 reverse transcriptase inhibitors and their preparation, pharmaceutical compositions and use in the treatment of AIDS |
2013 |
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Preparation of aryl-heteroxy acethydrazide derivatives as anti-influenza virus agents |
2013 |
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Method for preparation of (2-(2-oxy-4-thio pyrimidine)ethoxy)methyl phosphonate ester derivative and their application for preparation of anti-HBV drugs |
2012 |
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(2-(3-Methylthio-1,2,4-thiadiazine)ethoxy) methyl phosphonate derivative, its preparation and application |
2012 |
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Preparation of thiadiazine derivatives as anti-HIV agents |
2012 |
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Pyridazine derivatives as HIV-1 reverse transcriptase inhibitors and their preparation, pharmaceutical compositions and use in the treatment of AIDs |
2012 |
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Preparation of 1,2,3-thiadiazole derivatives for treatment of HIV infection |
2012 |
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Preparation of six-membered heteroaryl fused imidazole thioacetamide derivatives as anti-HIV agents |
2012 |
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N2,N4-Bis-substituted-2H,4H-pyrrolo[1,2-b][1,2,4,6] thiotriazine-1,1,3-trione derivatives useful in the treatment of AIDS and their preparation |
2012 |
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N-1-substituted piperidine-4-arylamine derivative useful in the treatment of HIV infection and its preparation |
2011 |
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2-Aryl methylthio-6-(tetrahydroquinolin-1-ylmethyl)- 4-pyrimidone derivatives useful in the treatment of HIV-1 and their preparation |
2011 |
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Preparation of benzoxazole derivatives as inhibitors of influenza virus |
2011 |
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