Recent Publications/Highlighted Publications

Discovery of a Novel Thienopyrimidine Derivative as a Potent Dual URAT1/GLUT9 Inhibitor with Enhanced Urate-Lowering Efficacy, Superior Pharmacokinetics, and Favorable Safety Profile for Gout and Hyperuricemia

Journal of Medicinal Chemistry (2026)

Antiviral drug discovery and development: challenges and future directions

Signal Transduction and Targeted Therapy (2026)

Breakthrough progress in the structural determination of the monkeypox virus I7L protease and the design of targeted inhibitors

Chinese Chemical Letters (2026)

Structural biology of HIV-1 reverse transcriptase allosteric inhibitors for drug design

ACTA Pharmaceutica Sinica B (2026)

Clinical insight-driven novel drug development: Multidisciplinary integration and transformative opportunities

ACTA Pharmaceutica Sinica B (2026)

Discovery of novel diarylpyrimidine derivatives as HIV-1 non-nucleoside reverse transcriptase inhibitors: Design, synthesis and biological activity evaluation

Bioorganic Chemistry (2026)

First-in-Class Quinoline-Dione-Derived PROTACs: Potent Degraders of Cdc25 Phosphatases for Antitumor Therapy

Journal of Medicinal Chemistry (2026)

Design, Synthesis, and Biological Evaluation of Highly Potent Boronic Acid (Boronate Ester)-Bearing Heteroaryldihydropyrimidine Derivatives as HBV Capsid Assembly Modulators

Journal of Medicinal Chemistry (2025)

Phenotypic Screening: A Cornerstone Engine for Discovering Original Anti-Infective Drugs

Journal of Medicinal Chemistry (2025)

Recent Advances in Long-Acting Antiviral Agents: Innovations in Design and Strategies for Extended Duration

Journal of Medicinal Chemistry (2026)

Decoding helical dynamics in viral replication: Cryo-EM unveils conserved assembly mechanisms and broad-spectrum antiviral targets

ACTA Pharmaceutica Sinica B (2025)

Stories behind drug discovery: Key figures, cutting-edge technologies, and blockbuster drugs

Innovation (2025)

Novel oxadiazole analogs as anticancer agents: Design, synthesis, in vitro and in vivo biological evaluation, and computer studies of sphingosine kinase inhibitors

Bioorganic & Medicinal Chemistry (2026)

Strategies for developing anti-CHIKV drugs

Science China-Chemistry (2026)

Protein degradation-based anti-infective drug research

ACTA Pharmaceutica Sinica B (2025)

Therapeutic approaches to addressing drug resistance by targeting membranes and associated structures

Drug Discovery Today (2025)

Multisite Occupancy and Multidimensional Optimization: Design and Evaluation of Piperazine-Thioureidobenzamide Derivatives as Potent HBV Capsid Assembly Modulators

Journal of Medicinal Chemistry (2025)

Structure- and Privileged Fragment-Based Iterative Optimization: Discovery of 2,4-Disubstituted-6-aminopyrimidines as Novel HIV-1 NNRTIs with Potent Activity against Drug-Resistant Strains and Favorable Safety Profiles

Journal of Medicinal Chemistry (2025)

Antiviral strategies based on targeted protein degradation: An overview of the literature and future outlook

European Journal of Medicinal Chemistry (2026)

Exploring the HIV-1 Reverse Transcriptase p51/p66 Interface: Structure-Based Design and Optimization of Novel 2,4,6-Trisubstituted Pyrimidines as Potent NNRTIs with Improved Resistance Profiles

Journal of Medicinal Chemistry (2025)

Discovery of a Baloxavir-Inspired Endonuclease Inhibitor That Prevents Herpes Simplex Virus 1 Replication in Cell Culture and In Vivo

Advanced Science (2025)

Anti-infective Drug Discovery: Harnessing Multimechanistic Molecules and Emergent Properties to Defeat Pathogenic Complexity

Journal of Medicinal Chemistry (2025)

Advances in click chemistry for drug discovery and development

Expert Opinion On Drug Discovery (2025)

Design, synthesis, and biological evaluation of dual-site HIV-1 inhibitors simultaneously targeting the NNRTI binding pocket and an adjacent site with favorable resistance profiles

Bioorganic Chemistry (2025)

ROS-induced allosteric regulation of NikR coordinates HP0910-mediated OMP2 methylation to modulate H. pylori biofilm dynamics and therapeutic targeting

Microbiological Research (2025)

Targeting the coronavirus membrane protein: A promising novel therapeutic strategy

ACTA Pharmaceutica Sinica B (2025)

Structural Analysis of HIV-1 RNase H Bound to a Galloyl Active Site Inhibitor and Computational Compound Modification

Biochemistry (2025)

Discovery of multi-target anti-gout agents from Eurycoma longifolia Jack through phenotypic screening and structural optimization

Nature Communications (2025)

Structure-Based Drug Design Yields Diarylpyrimidine Derivatives as Potent HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors

ACS Infectious Diseases (2025)

Further exploring the tolerant region II: Identification of 2,4,5-trisubsti-tuted pyrimidines as HIV-1 reverse transcriptase allosteric inhibitors with desirable antiviral activities and reduced cytotoxicity

European Journal of Medicinal Chemistry (2025)

Research projects

National Natural Science Foundation of China (NSFC), Contract grant numbers: 81573347

2016.01-2019.12

National Natural Science Foundation of China (NSFC), Contract grant numbers: 81102320

2012.01-2014.12

Research Fund for the Doctoral Program of Higher Education of China, Contract grant number: 20110131120037

2012.01-2015.12

The Science and Technology Development Project of Shandong Province, Contract grant number: 2014GSF118012

2015.01-2017.12

The Special Program of the Postdoctoral Science Foundation of China, Contract grant number:  2012T50584

2012.10-2013.10

The General Program of the Postdoctoral Science Foundation of China, Contract grant number: 20100481282

2011.01-2012.12

Research Project funded by JSPS (Japan Society for the Promotion of Science), Contract grant number: 12F02418

2012-2013

Shangdong Postdoctoral Innovation Science Research Special Program, Contract grant number: 201002023

2011.1-2013.06

Independent Innovation Foundation of Shandong University (IIFSDU), Contract grant number: 2010GN044

2010.10-2012.12

Patents

Preparation of imidazole derivatives as antitumor drugs. Faming Zhuanli Shenqing

2014

Preparation of heterocyclic compounds as   anti-HIV agents. Faming Zhuanli Shenqing

2011

Preparation of heterocycles useful for  preventing and treating HIV and influenza virus infection

2010

Method for preparation of 2-(2-substituted aryl-2H-1,2,4-triazole-3-mercapto)acetamide derivatives, and the preparation and medical application as anti-AIDS agent

2010

A process for preparing 2-(1,2,3-thiadiazol-5-ylthio)-acetamide derivatives

2009

Preparation of 1,2,3-selenadiazole derivatives as HIV inhibitors

2009

Preparation of 1-aryl-2-mercaptoimidazole derivatives as HIV-1 inhibitors

2009

Preparation of 2-[(4-phenyl-1,2,3-thiadiazol-5-yl)thio]-N-phenyl- acetamide derivatives as anti-HIV agents

2009

Imidazopyrazine derivatives as antiviral agents and their preparation, pharmaceutical compositions and use in the treatment of HIV infection

2014

2H-1,2,6-Thiadiazin-3(6H)-one-1,1-dioxide derivatives as antiviral agents and their preparation, pharmaceutical compositions and use in the treatment of HIV-1 infection

2014

Preparation of pyrimidine mercapto-acetamides derivatives. Faming Zhuanli Shenqing

2014

Substituted pyrazolo[1,5-a]pyrimidine derivative, its  preparation method and application in preparation of drug for treatment and prevention of human immunodeficiency virus (HIV) infection

2014

m-Diarene-pyrimidine derivatives as HIV-1 reverse transcriptase inhibitors and their preparation, pharmaceutical compositions and use in the treatment of HIV infection

2014

Preparation of substituted thiadiazine triketone derivatives for preventing and treating AIDS

2013

Triazolopyrimidines as HIV-1 reverse transcriptase inhibitors and their preparation, pharmaceutical compositions and use in the treatment of AIDS

2013

Preparation of aryl-heteroxy acethydrazide derivatives as anti-influenza virus agents

2013

Method for preparation of (2-(2-oxy-4-thio pyrimidine)ethoxy)methyl phosphonate ester derivative and their application for preparation of anti-HBV drugs

2012

(2-(3-Methylthio-1,2,4-thiadiazine)ethoxy) methyl phosphonate derivative, its preparation and application

2012

Preparation of thiadiazine derivatives as anti-HIV agents

2012

Pyridazine derivatives as HIV-1 reverse transcriptase inhibitors and their preparation, pharmaceutical compositions and use in the treatment of AIDs

2012

Preparation of 1,2,3-thiadiazole derivatives for treatment of HIV infection

2012

Preparation of six-membered heteroaryl fused imidazole thioacetamide derivatives as anti-HIV agents

2012

N2,N4-Bis-substituted-2H,4H-pyrrolo[1,2-b][1,2,4,6] thiotriazine-1,1,3-trione derivatives useful in the treatment of AIDS and their preparation

2012

N-1-substituted piperidine-4-arylamine derivative useful in the treatment of HIV infection and its preparation

2011

2-Aryl methylthio-6-(tetrahydroquinolin-1-ylmethyl)- 4-pyrimidone derivatives useful in the treatment of HIV-1 and their preparation

2011

Preparation of benzoxazole derivatives as inhibitors of influenza virus

2011